منابع مشابه
Various Solvent Systems for Solubility Enhancement of Enrofloxacin
Solubility enhancement of antimicrobial drug enrofloxacin has been studied using a series of co-solvents and surfactants. Aqueous solubility of enrofloxacin could be increased up to 26 times. Co-solvents alone produced only small increase in solubility. However, the combined effect of co-solvents and buffer was synergistic and a large increase in solubility could be attained. Ionic surfactants ...
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Solubility enhancement of meloxicam and rofecoxib, which are poorly soluble in water, was attempted. These are available in the form of solid dosage forms but not in solution dosage forms due to their low aqueous solubility. In this work, aqueous solubility of meloxicam and rofecoxib was improved using the biocompatible solvents such as ethanol, propylene glycol, glycerin, and PEG 400. Physico-...
متن کاملThe role of COX inhibitors in various physiological systems
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) act by inhibiting the cyclo-oxegenase (COX) enzyme, which is responsible for prostaglandin H2 (PGH2) synthesis. Inhibition of PG results in pain relief and reduction of inflammation.1,2,3,4 However, the majority of NSAIDs inhibit PGs found all over the body and not only at the location of the inflammation, causing side effects like gastro...
متن کاملCOX-2 inhibitors.
Cyclooxygenase-2 (COX-2) inhibitors constitute a new group of non-steroidal anti-inflammatory drugs (NSAIDs) which, at recommended doses, block prostaglandin production by cyclooxygenase-2, but not by cyclooxygenase-1. Two COX-2 inhibitors are currently available in Australia--celecoxib, which is taken twice daily, and rofecoxib, which is taken once daily. Both drugs act rapidly in providing pa...
متن کاملSolubility and solvation in mixed solvent systems
The solubility of solutes in mixed solvents depends primarily on the solvation of the solutes or their constituent ions by the components of the solvent mixtures. Complications may arise if different crystal solvates are formed or if solute-solute interactions are appreciable. In their absence the standard molar Gibbs energies of solution measure the corresponding quantities of solvation, ASOIV...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2003
ISSN: 1530-9932
DOI: 10.1208/pt040333